Objectives This study aimed to explore the relationship between dermatomyositis (DM) and thyroid cancer and the role of transcriptional intermediary factor 1γ (TIF-1γ) in the pathogenesis of cancer-associated DM. Methods Five cases of DM with thyroid cancer, including one with metastasis, were summarized and analyzed....
Xia-Yan Xu, Yi-Chi Zhang, Zi-Xuan Huang et al.· Frontiers in Immunology· 0 citations
This study confirmed the pathogenicity of the Y139C heterozygous mutation, providing supporting evidence for CTLA-4 haploinsufficiency and revealed that compensatory mechanisms arise in response to compromised trans-endocytosis.
BACKGROUND & AIMS
Immune tolerance after transplantation reduces immunosuppression-related complications and improves the overall survival rates. The unique tolerogenic microenvironment of the liver enables a proportion of liver transplantation (LT) recipients to develop tolerance with intact liver function. However, t...
Yong-Bo Liu, Bing-Ran Wang, Di Sun et al.· Journal of Hepatology· 0 citations
This work demonstrates that GRP75 deficiency disrupts CD8+ T cell fate, leading to defective T cell homeostasis and impaired memory differentiation, and establishes GRP75 as a pivotal mitochondrial checkpoint that coordinates metabolic state and functional fate in CD8+ T cells.
Fan Zhao, Pengfei Wang, Zejin Cui et al.· Cell Death and Differentiati...· 0 citations
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