Author

Lin Yang

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Jul 2026

Single-nucleus transcriptomics-based drug screening platform for focal cortical dysplasia.

A transcriptome-guided framework for linking multicellular disease signatures to candidate therapeutic strategies in refractory epilepsy is established, and four compounds reduced seizure-like activity in vivo, as assessed by behavioral assays and local field potential recordings.

Chuantao Fang, Guilin Meng, Lin Yang et al. · Molecular Psychiatry · 0 citations

Open access Jul 2026

Delayed astrocyte development impairs Sema6a-Plxna2/4-mediated astrocyte-neuron crosstalk and causes depressive-like behavior

It is demonstrated that Egfr knockout during the critical period of neuronal maturation results in a transient absence of astrocytes, with recovery observed in adult mice, and developmental disruption of EGFR signaling leads to transient astrocyte loss and impaired astrocyte–neuron crosstalk.

Xin Jiang, Yanqing Qi, Lin Yang et al. · Nature Communications · 0 citations