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Single-nucleus transcriptomics-based drug screening platform for focal cortical dysplasia.

Chuantao Fang Guilin Meng Lin Yang Li-Jun Wang Yanfeng Tan Jingjing Guo Ying Shi Xianming Liu Rui Zhao Min Zhang Lei An Fang Yuan Dashi Qi
Jul 2026 · Molecular Psychiatry · 0 citations · 50 references
Medicine

TL;DR

A transcriptome-guided framework for linking multicellular disease signatures to candidate therapeutic strategies in refractory epilepsy is established, and four compounds reduced seizure-like activity in vivo, as assessed by behavioral assays and local field potential recordings.

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