Summary Acetyl-CoA is a molecule central to cellular metabolic homeostasis. As part of the secretory pathway, acetyl-CoA is imported into the endoplasmic reticulum (ER) by a membrane-bound transporter AT-1 (SLC33A1). AT-1 mutations have been linked to peripheral neuropathy, developmental delay with premature death, and...
Eric R. McGregor, C. McGill, N. Arp et al.· iScience· 0 citations
High-throughput quantitative proteomics across diverse biological conditions, including varying perturbations and temporal changes, is critical for elucidating disease mechanisms and treatment responses. Advances in mass spectrometry and isobaric labeling technologies have enabled powerful multiplexed analyses; howev...
Jing-Wei Zhang, Zi-Cong Wang, Ya-Jing Lu et al.· Journal of the American Soci...· 0 citations
It is demonstrated that TEMI overcomes the long-standing spatial limitations of MSI without requiring hardware modifications, ensuring compatibility with existing MSI instruments and promoting broad accessibility and adoption within the research community.
Hua Zhang, Lang Ding, Thao U. Duong et al.· Nature Protocols· 0 citations
This work provides a foundational framework for optimizing spectral library selection in neuropeptidomics and underscores the importance of model-specific biases when analyzing structurally diverse endogenous peptides.
Lauren Fields, Emily M. Hubecky, Kendra G. Selby et al.· bioRxiv· 0 citations
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