Ling-Ling Chen

Chimeric archaeal BHB-human pre-tRNA scaffold HARBOR system enables versatile production of functional circular RNA modalities

Circular RNAs (circRNAs) exhibit superior intrinsic stability and lower immunogenicity compared with linear RNAs, rendering them promising modalities for biomedical and biotechnological applications. Here, we establish the HARBOR (Human-Archaeal RNA Backbone for Overexpression of circular RNA) system, an engineered end...