Author

Liu-Qing Chen

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Open access Oct 2026

Case Report: Successful treatment of generalized pustular psoriasis with concomitant renal insufficiency using spesolimab: a report of two cases

Generalized pustular psoriasis (GPP) is a rare, severe, and potentially life-threatening neutrophilic dermatosis. Management focuses on rapid control of acute flares and prevention of recurrence. Advances in understanding the central role of interleukin-36 (IL-36) signaling in GPP pathogenesis have shifted the treatmen...

You Xie, Feng Cheng, Zi-Lu Qu et al. · Frontiers in Immunology · 0 citations

Case report Open access Aug 2026

Granular parakeratosis associated with the use of laundry sanitizers containing benzalkonium chloride: a case report

Background Granular parakeratosis (GP) is a rare benign inflammatory dermatosis that preferentially involves the axillae and other intertriginous, friction-prone skin sites and typically presents with pruritic erythema and scaling. Cases associated with benzalkonium chloride (BAC) exposure have rarely been systematical...

Mei-Zhen Fang, Jing-Qiu Zhang, Zi-Lu Qu et al. · Frontiers in Allergy · 0 citations

#protein folding Review Open access Oct 2026

Endoplasmic reticulum stress in autoimmune skin diseases: immune activation, cutaneous cell damage, and therapeutic advances

Endoplasmic reticulum stress (ERS) arises when the protein-folding load, or perturbations in calcium and redox homeostasis, outpace the adaptive capacity of the endoplasmic reticulum (ER). The unfolded protein response (UPR) initially reduces secretory load and restores proteostasis. Persistent stress can redirect the...

Jia-Xi Qiao, Jia Chen, Jin-Bo Chen et al. · Frontiers in Immunology · 0 citations