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Lorenzo Campedelli

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Review Open access Oct 2026

Magnesium supplementation for anxiety and depression: a systematic review of clinical evidence and mechanistic insights

Magnesium is an essential cofactor in numerous enzymatic reactions regulating neuronal excitability, neurotransmission, and stress response. Deficiency has been linked to affective dysregulation through altered N-methyl-D-aspartate (NMDA) and γ-aminobutyric acid (GABA) signaling, impaired neuroplasticity, and activatio...

Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al. · 0 citations
Review Sep 2026

Lithium exposure and risk of dementia and Alzheimer's disease: A systematic review and meta-analysis.

BackgroundAlzheimer's disease (AD) is the most common cause of dementia, affecting over 55 million people worldwide with no established disease-modifying treatments. Lithium has emerged as a potential neuroprotective agent through multiple molecular mechanisms, and observational studies suggest reduced dementia risk am...

Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al. · 0 citations
#generative ai Review Open access Sep 2026

Emotional Reliance on Artificial Intelligence: A Scoping Review of AI Companionship and Mental Health Implications

Eotional reliance on AI represents an emerging clinical phenomenon with addiction-like features requiring specific diagnostic frameworks, evidence-based interventions, and ethical design guidelines and future research should prioritize longitudinal studies examining developmental impacts and neurobiological investigati...

M. Lastretti, M. Manchia, Matteo Fraschini et al. · 0 citations
Review Open access Jul 2026

The Gut–Brain Axis in Depression: A Systematic Review of Microbiota and Mental Health

Gut microbiota dysbiosis represents a biologically plausible mediator of depression pathophysiology, with a recurrent dysbiotic pattern, characterised by depletion of butyrate-producing taxa and enrichment of pro-inflammatory genera, showing emerging diagnostic and therapeutic potential.

Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al. · 0 citations

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