AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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Parkinson’s disease (PD) is an incurable progressive neurodegenerative condition, which is characterized by a selective loss of dopaminergic neurons in the substantia nigra and subsequent development of motor impairment along with a non-motoric syndrome. It has a multifactorial etiopathogenesis, including oxidative str...
Fisetin represents a promising multi-target therapeutic candidate for the management of inflammation-associated neurodegenerative disorders and simultaneously targets interconnected inflammatory, oxidative, apoptotic, and proteostatic pathways implicated in neurodegeneration.
Given the multifaceted interaction of various mediators in the pathophysiology of PD, and the potential of baicalein to regulate these processes, the current review has been structured to examine the mechanisms by which baicalein can produce its antiparkinsonian effects.
Combined in silico and experimental findings highlight hesperidin’s strong binding to key molecular targets, whereas experimental evidence also confirms its antioxidant, anti-inflammatory, and anti-apoptotic effects, supporting its potential as a disease-modifying candidate in PD therapy.
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