Skip to content
Review

Mechanistic insights into anti-parkinson effect of baicalein: from neuroinflammation and cell death to neurogenesis and synaptic plasticity

Jul 2026 · Molecular Biology Reports · Vol 53 · 0 citations · 111 references
Medicine

TL;DR

Given the multifaceted interaction of various mediators in the pathophysiology of PD, and the potential of baicalein to regulate these processes, the current review has been structured to examine the mechanisms by which baicalein can produce its antiparkinsonian effects.

View source

Similar papers

Aug 2026

Astragalin confers coordinated neuroprotection in Parkinson's disease models through modulation of neurotrophic, anti-inflammatory, and synuclein-related pathways.

The natural flavonoid Astragalin concurrently addresses three core pathological processes in PD, namely dopaminergic neuron degeneration, α-synucleinopathy, and neuroinflammation, through coordinated modulation of interconnected molecular pathways.

Jun Wang, Jie-Yu He, Qin Huang et al. · 0 citations
Review Aug 2026

Hesperidin as a Neuroprotective Agent in Parkinson’s Disease: Mechanistic Insights and In Silico Validation

Combined in silico and experimental findings highlight hesperidin’s strong binding to key molecular targets, whereas experimental evidence also confirms its antioxidant, anti-inflammatory, and anti-apoptotic effects, supporting its potential as a disease-modifying candidate in PD therapy.

Seyawash Ghani, Diksha Dalal, Anish Singh et al. · 0 citations
Open access Jul 2026

Sarsasapogenin Improves Pathological Phenotypes in MPTP/MPP+-Induced Parkinson's Disease Models: Synergistic Actions of Neurite Outgrowth, Neurotransmitter Modulation, and Anti-Inflammation.

Sarsasapogenin exerts comprehensive neuroprotective effects in preclinical PD models via synergistic modulation of dopaminergic neuronal survival, neurotransmitter balance, inflammatory inhibition, and neurite outgrowth.

Wen-Di Deng, Jin-Feng Hong, Weixia Li et al. · 0 citations
Sep 2026

Gomisin N ameliorates autophagy-neuroinflammation imbalance in Parkinson's disease models via modulating the ATG16L1/NLRP3 axis.

BACKGROUND Parkinson's disease (PD) is characterized by dopaminergic neuron loss, α-synuclein accumulation, and sustained neuroinflammation. Autophagy can remove pathogenic α-synuclein and restrain NLR family pyrin domain containing 3 (NLRP3) inflammasome activation. Gomisin N (GN), a lignan from Schisandra chinensis,...

Cheng-Fu Su, Zhi-Qiang Deng, Ka-Yee Ying et al. · 0 citations
Review Open access Sep 2026

The Role of Curcumin in Neurogenesis and Neuroprotection in Alzheimer’s disease: From Molecular Mechanisms to Clinical Evidence

Alzheimer's disease (AD) is the most common form of senile dementia worldwide and is a progressive and irreversible neurodegenerative disorder, which represents a huge socioeconomic burden on modern healthcare systems. The neuropathology of AD is characterised by a very complex, interconnected cascade of cellular event...

V. S, Sarupruthiya M, Jeevitha D et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.