SPROTify: A protein-centric machine learning framework for small protein identification with validation in cancer proteomics.
In six cancer proteomics cohorts, 334 small-protein candidates were identified, including 36 differentially expressed small proteins (DESPs) exhibiting strong cancer-type specificity, suggesting specialized functional roles in tumor biology and underscore the potential of SPROTify as a robust, protein-centric engine fo...
Chien-Han Yuan, Pei-Wen Wu, Ing-Luen Shyu et al.
· New Biotechnology · 0 citations