Author

Lu-Yang Wang

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#gene editing Open access Sep 2026

HOPX regulates the development and lineage progression of human stem cell-derived outer radial glia-like cells.

Using CRISPR-Cas9 gene editing in human pluripotent stem cells, HOPX is identified as an important regulator of oRG-like cell maintenance and the neurogenic-gliogenic balance, providing insight into the molecular programs governing human neural progenitor expansion.

Xiao-Xue Dong, Wendy W. Y. Choi, Mai Ahmed et al. · Stem Cell Reports · 0 citations

Open access Aug 2026

Early MATR3 loss and distinct neurodegenerative molecular signatures precede the onset of neuropathology in motor neurons and Purkinje cells of MATR3 S85C knock-in mouse model of ALS

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, leading to progressive muscle weakness and motor impairment. Growing evidence indicates that cerebellar Purkinje cells, which play a central role in motor coordination, are also affected in ALS. However, it is unclear whether the molecular events that initi...

Katarina Maksimović, Rambabu Majji, Jhune Rizsan Santos et al. · bioRxiv · 0 citations