Author

Lucas Sekele

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Open access Oct 2026

Computational Analysis of the Homologous Mouse Double RINGs Interface for Targeted Anticancer Drug Design

Background/Objectives: The new yearly 1.1 million cancer cases and considerably increasing mortality, after decades of decline, require urgent and effective therapy. Targeted anticancer therapy is an attractive strategy for treating cancer by targeting critical receptors. The MDM2-MDMX RING heterodimer downregulates th...

Adeniyi T. Adewumi, Lucas Sekele, Wande M. Oluyemi et al. · Biomedicines · 0 citations

#protein folding Open access Oct 2026

Over-expression, purification, and characterisation of Mycobacterium tuberculosis MPT64 from inclusion bodies.

Tuberculosis remains among the top ten deadliest infectious diseases worldwide, primarily due to delayed diagnosis, co-infection with HIV, and multidrug resistance. Targeting early secreted mycobacterial antigens, including MPT64, ESAT6, and CFP10, may be a viable strategy for detecting the onset of tuberculosis. Altho...

Lucas Sekele, Adeniyi T. Adewumi, Amanda Skepu et al. · Protein Expression and Purif... · 0 citations