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Author

Luowei Yuan

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2 papers indexed here

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Jul 2026

Designing Fidelity of CRISPR-Cas Endonucleases by Kinetic Insights

A PLM-assisted physics-driven approach is presented that utilizes atomistic molecular dynamics simulations and automated path searching to efficiently obtain the complete kinetic insights, including the transition state structures, for the conformational changes of Cas before DNA cleavage.

Huihui Liu, Zhenyu Zhou, Luowei Yuan et al. · 0 citations
#gene editing Open access Aug 2026

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

Findings establish Cas7-11 as a precise and efficient RNA knockdown tool for functional studies in embryonic development and stem cell biology, providing a versatile alternative to DNA-based gene-editing approaches.

Huan Yan, Imtiaz Ul Hassan, Kai Yan et al. · 0 citations