Author

Lushan Wang

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Open access Aug 2026

Reconstruction of a cross-family chitinase cocktail for efficient chitobiose production guided by the secretome of Streptomyces sp. F-3.

The enzymatic conversion of chitin to chitobiose is of significant interest due to its broad biological applications. However, the limited functional diversity and insufficient synergism of chitinase systems constrain catalytic efficiency and industrial applicability. In this study, we rationally reconstructed a cross-...

Sha Zhao, Fei-Yue Wen, Xiao-Meng Sun et al. · Food Chemistry · 0 citations

Open access Aug 2026

Collaborative multi-agent intelligence uncovers subtype-selective allosteric sites at GPCR-lipid interaction interface

A five-agent workflow to systematically identify divergent protein-membrane-interface sites across class A GPCRs and exploit them for selective allosteric ligand discovery is developed, establishing a scalable strategy for translating GPCR membrane-interface divergence into precise allosteric sites and testable subtype...

Jing-Yi Zhu, Hengde Li, Min Xiao et al. · bioRxiv · 0 citations

Aug 2026

Dual Engineering of the Hydrophobic Core and Functional Loop Reshapes the Conformational Energy Landscape for Significantly Enhanced Xylanase Activity and Thermostability.

The industrial application of enzyme catalysts is often constrained by the trade-off between thermostability and catalytic activity. Here, a region-focused engineering strategy was applied to a thermophilic GH10 xylanase to simultaneously improve both properties. The strategy integrates qProtein-guided hydrophobic clus...

Zhaoran Li, Zhixin Dou, Sha Zhao et al. · Journal of Agricultural and... · 0 citations