Background: Flaviviruses such as dengue virus and Zika virus rely on host cellular factors to complete their replication cycle. Host proteins involved in cytoskeleton dynamics and vesicular trafficking may represent potential therapeutic targets. Bioactive aminoestrones have shown antiviral activity, although their mol...
Ednner E. Victoria-Blanco, Lydier De Gracia· Panamanian Journal of Clinic...· 0 citations
Established genomic and population-level evidence support a Likely Pathogenic, loss-of-function classification for the TTN p.Arg3936Ter variant, which introduces a premature termination codon predicted to generate a truncated titin protein of 3,935 amino acids and is predicted to escape nonsense-mediated decay.
Lydier De Gracia, O. Espinosa, L. Sotillo et al.· Gene Clin Genom· 0 citations
The findings support genetic counseling, cascade testing, and cardiovascular surveillance, however, the current clinical and segregation data do not establish definitive causality for hypertrophic cardiomyopathy or conduction disease.
JoseCedeno, Carlos Chellaram, Carolina Vega et al.· Frontiers in Medical Case Re...· 0 citations
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