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Author

Lydier De Gracia

3 papers indexed here

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Open access 2026

Bioinformatic Prediction of Cellular Targets of Aminoestrones through Molecular Docking: Implications for Flavivirus Replication and Cell-to-Cell Transmission.

Background: Flaviviruses such as dengue virus and Zika virus rely on host cellular factors to complete their replication cycle. Host proteins involved in cytoskeleton dynamics and vesicular trafficking may represent potential therapeutic targets. Bioactive aminoestrones have shown antiviral activity, although their mol...

Ednner E. Victoria-Blanco, Lydier De Gracia · 0 citations
#protein folding Open access Aug 2026

Computational Structural Modeling of the TTN p.(Arg3936Ter) Variant in a Panamanian Patient with Dilated Cardiomyopathy

Established genomic and population-level evidence support a Likely Pathogenic, loss-of-function classification for the TTN p.Arg3936Ter variant, which introduces a premature termination codon predicted to generate a truncated titin protein of 3,935 amino acids and is predicted to escape nonsense-mediated decay.

Lydier De Gracia, O. Espinosa, L. Sotillo et al. · 0 citations
Open access 2026

Familial Characterization of the DSC2 c.354+1G>T Splice-Site Variant Cardiac Disease

The findings support genetic counseling, cascade testing, and cardiovascular surveillance, however, the current clinical and segregation data do not establish definitive causality for hypertrophic cardiomyopathy or conduction disease.

JoseCedeno, Carlos Chellaram, Carolina Vega et al. · 0 citations

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