Author

M. Abbaszadegan

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#protein folding Open access Oct 2026

CNPY3 variants associated with a recessive developmental and epileptic encephalopathy affect inflammasome and TLR function.

The authors' findings reveal separable effects on TLR trafficking, downstream signalling and inflammasome activation, identifying CNPY3 as a key regulator of multiple cellular pathways involved in inflammatory responses and neurodevelopment.

Vera Garloff, M. Grimmel, R. Maroofian et al. · EBioMedicine · 0 citations

2026

Allele-specific disruption of KRAS p.G12V in colorectal cancer cells using electroporated Cas9 RNPs

Objective(s): Colorectal cancer (CRC) is a major cause of mortality, and KRAS mutations drive tumorigenesis and therapy resistance. Although CRISPR-Cas9 enables precise genome editing, intracellular delivery of Cas9 ribonucleoproteins (RNPs) remains challenging. We evaluated direct electroporation of Cas9-sgRNA RNPs ta...

Firouzeh Morshedzadeh, Samaneh Sharif, M. Peymani et al. · Iranian Journal of Basic Med... · 0 citations