Early-Onset Appendiceal Adenocarcinoma (Age < 50 Years): Temporal Trends in Case Proportions, Histologic Patterns, and Survival Outcomes From SEER, 2000-2023.
Early-onset appendiceal adenocarcinoma accounts for approximately one in five cases nationally and carries distinct demographic and histologic features and survival was shown to be driven primarily by stage and tumor characteristics rather than by age alone.