A review of progression from tumor-induced neural remodeling and neural-like cell states to the sensory, autonomic, enteric, and systemic neuroendocrine axes that regulate antitumor immunity and how spatial omics resolves these interactions in situ is considered.
Tian-Hui Dong, Hidde Ploeger, T. Eichwald et al.· Journal for ImmunoTherapy of...· 0 citations
Simple Summary Cutaneous squamous cell carcinoma (cSCC) is the second most common type of skin cancer. Although anti-PD-1 immunotherapy has significantly improved treatment outcomes for patients with advanced disease, a substantial portion of individuals do not respond, and reliable pretreatment tools to predict succes...
Tara Coreanu, Ido Amir, N. Edri et al.· Cancers· 0 citations
Overall immune-cell composition was largely preserved despite differences in immune-cell distribution, spatial organization, and T cell clonality, and multi-cohort validation across complementary spatial and single-cell platforms identified consistent alterations in innate-adaptive immune organization in immunosuppress...
Shorook Naara, V. Kochat, Xiayu Rao et al.· Cell· 1 citation
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