p38 MAPK inhibition safeguards genome integrity during gene editing of hematopoietic stem and progenitor cells.
Ex vivo genome editing of hematopoietic stem and progenitor cells (HSPCs) holds significant therapeutic potential but remains constrained by genotoxic risks associated with nuclease-induced DNA double-strand breaks, DNA donor template delivery and sensing, and proliferation-induced stress during ex vivo manipulation. T...
Roberta Vacca, Lucrezia della Volpe, Nicolò Gualandi et al.
· Molecular Therapy · 0 citations