This work conducted a species-wide genome-wide association study of invasion and compared the prevalence of significant unitigs in GPSC1 and GPSC21 to identify invasion-associated variants differentiating them, and highlighted candidate proteins that may help explain invasiveness and could be explored as vaccine antige...
M. Pesonen, O. Lorenz, M. du Plessis et al.· bioRxiv· 0 citations
OBJECTIVES
Pneumococcal conjugate vaccines (PCV) have reduced antimicrobial-resistant invasive pneumococcal disease (IPD) globally. We evaluated trends in antimicrobial-resistant IPD and pneumococcal lineages before and after PCV13 introduction in South Africa.
METHODS
We analysed national, laboratory-based IPD surve...
Cebile Lekhuleni, K. Ndlangisa, L. De Gouveia et al.· Journal of Infection· 0 citations
Streptococcus pneumoniae is highly diverse, comprising over 100 serotypes and hundreds of genomic lineages amid widespread vaccination. While it can cause invasive pneumococcal disease (IPD) which exhibits pronounced seasonal spikes, the interplay between pneumococcal diversity and environmental drivers remains unexplo...
S. Belman, Cebile Lekhuleni, J. Kleynhans et al.· Nature Microbiology· 1 citation
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