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Open access Sep 2026

Replication-coupled chromatin assembly cooperates with ATR/CHK1 signaling to suppress DNA damage and premature MMB-dependent mitotic transcription

Faithful genome duplication requires coordination of DNA replication, chromatin assembly, and checkpoint signaling to prevent inappropriate mitotic progression. Using a targeted siRNA screen for factors modulating CHK1 inhibitor-induced DNA damage and premature mitotic entry, we identified replication-coupled chromatin...

Devi Bala Murugan, D. Gertzmann, Merima Ramic et al. · 0 citations
Open access Sep 2026

TRRAP enables MMB-dependent mitotic transcription and determines sensitivity to CHK1 inhibition.

Precise temporal activation of mitotic genes is essential for proper cell-cycle progression, yet the chromatin-based mechanisms coordinating this process remain incompletely understood. The B-MYB-MuvB (MMB) complex is a key regulator of mitotic gene expression and becomes hyperactivated following inhibition of the ATR-...

Franziska Liss, D. Gertzmann, Devi Bala Murugan et al. · 1 citation
Review Open access Sep 2026

Tales of destruction and repair: the changing view of MYC proteins in tumorigenesis.

Findings suggest that, through these activities, MYC proteins enhance the stress resilience of proliferating cells and enable tumor cells to sustain nonphysiological, oncogenic gene expression programs.

Laura Baranello, Dimitrios Papadopoulos, M. Eilers · 0 citations

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