Findings suggest that, through these activities, MYC proteins enhance the stress resilience of proliferating cells and enable tumor cells to sustain nonphysiological, oncogenic gene expression programs.
Abstract
MYC proteins are classically viewed as oncoproteins because they act as DNA-bound transcription factors that drive characteristic gene expression programs. Building on this view, recent work has shown that MYC proteins engage in multiple protein complexes that resolve transcription-associated stress and that they function as both DNA- and RNA-binding proteins. These findings suggest that, through these activities, MYC proteins enhance the stress resilience of proliferating cells and enable tumor cells to sustain nonphysiological, oncogenic gene expression programs.
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