The mechanisms of protein folding, misfolding, aggregation, and prion-like propagation in major neurodegenerative proteinopathies, including amyloid-beta and tau in Alzheimer's disease, alpha-synuclein in synucleinopathies, TDP-43 and FUS in ALS/FTLD, polyglutamine-expanded proteins, prion proteins, and rare hereditary...
A. Choudhury, Sneh Prabha, Mohammad Umar Saeed et al.· Expert opinion on therapeuti...· 0 citations
This review examines the molecular architecture and domain organization of Als3, including the N-terminal peptide-binding cavity (PBC) and the amyloid-forming region, as well as the regulatory network controlling ALS3 expression, which is one of the few targets for which a single treatment can act on both the fungal an...
A. Javaid, Nazia Tabassum, Y. M. Siddiqui et al.· Critical reviews in microbio...· 0 citations
These findings highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation, and highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation.
Faiza Iram, Ayesha Aiman, Deepanshi Vijh et al.· Journal of Cellular Biochemi...· 0 citations
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