Author

M. Jamal-Hanjani

2 papers indexed here

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Open access Sep 2026

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.

Cancer cachexia is a devastating wasting syndrome with no approved therapies. In this study, we identify the tumor-derived glycoprotein ADAMTSL4 as a circulating factor associated with body weight loss in preclinical cachexia models and patients with colorectal and lung cancers. In mice, Adamtsl4 overexpression convert...

J. Machado, Vignesh Karthikaisamy, Hermine Mohr et al. · Cancer Discovery · 0 citations

#gene editing Open access Sep 2026

Critical role for the TGF-β1/mTORC1 signaling axis in defining the transcriptional identity of CTHRC1+ pathologic fibroblasts

It is concluded that mTORC1 plays a key role in shaping the transcriptional identity of these fibroblasts, with implications for therapeutic inhibition of mTORC1 in fibrosis and cancer.

J. A. Wilson, Rachel Walters, G. Contento et al. · Science Advances · 0 citations