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Open access Sep 2026

Cyclic di-AMP signalling affects cell division and penicillin susceptibility in Streptococcus pneumoniae

Resistance to β-lactam antibiotics in the human pathogen Streptococcus pneumoniae is mainly attributed to the acquisition of mutated versions of pbp2x, pbp2b and pbp1a, encoding functional penicillin binding proteins with reduced affinity to β-lactams. This enables the bacterium to synthesise peptidoglycan required for...

Ragnhild Sødal Gjennestad, Silje Henriette Aadne, M. Kjos et al. · 0 citations
#protein folding Open access Sep 2026

Novel insights into the biosynthesis and diversity of leaderless multipeptide bacteriocins

To decipher conserved features involved in production of these bacteriocins, genome mining was used to identify 11 candidates for new multipeptide bacteriocins; four were obtained synthetically and confirmed to be bioactive peptides inhibiting important pathogens including Listeria monocytogenes and enterococci.

Thomas F. Oftedal, Simen Hermansen, Even A. Haslund et al. · 0 citations

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