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Open access Sep 2026

PGS-GS: a framework integrating polygenic scores and genomic selection in animal breeding

Abstract Genomic prediction has become a central paradigm in biology, enabling quantitative inference of genetic contributions to complex traits across humans, animals, and plants. Although genomic research in human genetics and animal breeding shares a highly homologous methodological foundation, significant barriers...

Jin-Bu Wang, Li-Li Du, Zhi-Da Zhao et al. · 0 citations
#gene editing Open access Sep 2026

Multi-layer Cis-molQTLs Reveal Regulatory Architecture and Enhance Heritability Explanation for Complex Traits in Cattle.

Genome-wide association study (GWAS) analyses have identified numerous loci associated with economic traits in cattle. Many of these loci reside in noncoding regions, and the regulatory mechanisms through which they influence complex traits remain poorly understood. Here, we integrated 657 RNA-seq libraries from 275 Hu...

Shiyuan Qiu, Li-Li Du, Bo-Yu Zhang et al. · 0 citations

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