Author

M. Merad

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Open access Sep 2026

A serpin-myeloid axis in pancreatic cancer heterogeneity and immune evasion.

Pancreatic ductal carcinoma (PDAC) is characterized by a highly immunosuppressive, extracellular matrix-rich microenvironment, yet tumours display marked heterogeneity1-4. This raises the question of whether immune resistance is a global tumour property or is organized within spatially restricted niches. Here, using Pe...

C. Falcomatà, Maximilian M. Schaefer, Bhavya Singh et al. · Nature · 0 citations

Open access Sep 2026

B cells sustain tumor-specific CD4 T cells to promote response to PD-1 targeted therapy

Immunotherapy transformed cancer treatment, yet precise correlates of response remain to be defined. While intratumoral follicular helper like (Tfhl) CD4 T cells and IgG1+ B cells have been associated with improved outcomes to PD-1 blockade for hepatocellular carcinoma (HCC), their mechanisms contributing to response a...

A. Vaidya, Étienne Humblin, Nataliya Prokhnevska et al. · bioRxiv · 0 citations

Open access Jul 2026

An IL-34–IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression

It is shown that KRASG12D mutations in lung epithelium drive proliferation of resident, embryonically-derived alveolar macrophages, which then promote tumor cell proliferation and protection from ferroptosis, leading to tumor progression.

Jaroslav Zak, Hui Chen, Erpei Wang et al. · bioRxiv · 0 citations