Open access
Aug 2026
ATM inhibition potentiates the anticancer activity of pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides in colorectal cancer cells in vitro
The results indicate that MM compounds exhibit measurable anticancer activity in 3D spheroid models and that their combination with ATM inhibition modulates both viability and spheroid morphology, as reflected by changes in ATP levels, core size, and diffusion parameters.
M. Kciuk, Katarzyna Wanke, M. Mojzych et al.
· Scientific Reports · 0 citations