ATM inhibition potentiates the anticancer activity of pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides in colorectal cancer cells in vitro

Design, robust synthesis, and anti-liver cancer activity of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives: In vitro, gene expression, DNA damage, and DNA fragmentation.

A novel series of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives tested as anticancer agents against a panel of cancer cell lines, and the mechanism of action of the most active compounds against liver cancer was explored through gene expression, DNA damage, and DNA fragmentati...

Discovery of novel pyrazolo[3,4-d]pyrimidine-6-amine derivatives as potent polo-like kinase 2 inhibitors.

The design and synthesis of novel PLK2 inhibitors, featuring pyrazolo[3,4-d]pyrimidine derivatives, are reported, establishing pyrazolo[3,4-d]pyrimidine derivatives as promising PLK2 inhibitors with strong therapeutic potential for colorectal cancer.

Novel benzofuran-furan-pyrano[2,3-c]pyrazole hybrids as potential anticancer agents: design, synthesis, in silico profiling, and multi-mechanistic biological evaluation

It is demonstrated that benzofuran-furan-pyrano[2,3-c]pyrazole hybrids possess promising multifaceted in vitro anticancer activity by inhibiting cancer cell proliferation, migration, invasion, and clonogenicity while inducing ROS-mediated mitochondrial apoptosis, highlighting these hybrid scaffolds as attractive candid...

Thieno[2,3-d]pyrimidine scaffold optimization for synergistic c-Met/STAT3 blockade: Synthesis, structure-activity relationships, in vitro potency, and apoptotic pathways in colorectal cancer.

Compounds 17d and 17e were found to be the most potent and exhibited significant anticancer activity across a wide range of cancer cell lines within the NCI-60 panel and are promising leads for further development of dual c-Met/STAT3 inhibitors for treating colorectal cancer.

Methyl-substituted 1,10-phenanthroline derivatives in copper(II) complexes enhance antitumor activity and inhibit NHE1 in MDA-MB-231 breast cancer cells

Pyrimidine- and furo[2,3-d]pyrimidine-isoxazole hybrids and their Re(i) tricarbonyl complexes with antiproliferative activity against hematological malignancies

Pyrimidine and furo[2,3-d]pyrimidine derivatives have emerged as promising anticancer agents that act through multiple mechanisms, including modulation of downstream signaling pathways such as a JAK2/STAT3 cascade. Herein, we report the synthesis of novel pyrimidine- and furo[2,3-d]pyrimidine-isoxazole hybrids via base...