The
APOEε4
allele is the strongest known genetic risk factor for late-onset Alzheimer disease (AD). However, the risk effect of
APOEε4
varies substantially by ancestry, with individuals of African ancestry (AF) demonstrating markedly lower risk compared to those of European ancestry (EU). This difference in r...
M. D. M. Muniz Moreno, K. Celis, F. Rajabli et al.· Frontiers in Aging Neuroscie...· 0 citations
An APOE-independent polygenic risk score for Alzheimer’s disease derived from multiancestry GWAS summary statistics shows consistent associations with cognitive, imaging, biomarker and neuropathological features in diverse populations.
N. Kurniansyah, S. Tasaki, H. Rehman et al.· Nature Genetics· 0 citations
Heritability estimates suggested that common variants explain much of genetic risk among APOE-{varepsilon}4 carriers, while unexplained heritability remains in non-carriers in the Amish, and GWAS confirmed APOE-{varepsilon}4 as the strongest genetic determinant of AD in the Amish.
Yi-Ning Liu, Yeunjoo E. Song, Wei-Huan Wang et al.· medRxiv· 0 citations
Epigenetic aging clocks based on DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), and environmental and social stressors. However, methylation clocks have not been comprehensively validated in genetically diverse individual...
Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.
Lu Zeng, Atlas Khan, Kathryn C. Fitzgerald et al.· Nature Genetics· 0 citations
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