Author

M. Roest

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Sep 2026

ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP.

BACKGROUND Immune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy. iTTP pathophysiology is based on severe ADAMTS13 deficiency caused by autoantibodies, leading to accumulation of ultra-large von Willebrand factor (VWF) multimers and microvascular thrombosis. Engineered ADAMT...

Yun-Peng Xue, M. Roest, S. J. Humphreys et al. · Journal of Thrombosis and Ha... · 1 citation

#protein folding Open access Oct 2026

Short-Term Dietary Exposures and Thrombin Generation in Tanzanian Men: Exploratory Coagulation-Focused Analysis of a Randomized Dietary-Switch Trial.

BACKGROUND Rapid dietary transitions in sub-Saharan Africa may alter coagulation profiles; however, this remains poorly characterized. METHODS An open-label dietary-intervention trial in Tanzania enrolled 77 healthy men aged 20 to 40 years. They underwent 1 of 3 interventions (n=22 per arm): heritage-to-Western-style...

Eka Patricia Kisali, M. Roest, T. Pecht et al. · Arteriosclerosis, Thrombosis... · 0 citations

Open access Sep 2026

Thrombin dynamics and clinical events in cirrhosis: low prothrombin conversion predicts bleeding risk

Pro- and anti-coagulant factors are significantly altered in liver cirrhosis resulting in an increased bleeding and thrombosis risk. The thrombin generation (TG) test often seems unaltered in cirrhosis, indicating that a new hemostatic balance is reached. TG is determined by prothrombin conversion and thrombin inactiva...

R. Willems, A. Zanetto, E. Campello et al. · Frontiers in Cell and Develo... · 0 citations