Modulation of Electrophysiology and Plaque Aggregation in Huntington’s Disease Patient-Derived Cells by Picosecond Pulsed Electric Fields
Huntington’s Disease (HD) is a fatal, autosomal dominant neurodegenerative disorder characterized by progressive motor and cognitive decline. Unstable expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin gene, often exceeding 35–40 repeats, results in an extended polyglutamine (PolyQ) tra...