Ulcerative colitis (UC); as one of the inflammatory bowel diseases (IBD), arises from chronic inflammation of the intestinal tract. In this study, we addressed the possible protective mechanisms of vonoprazan, as a potassium-competitive acid blocker, on dextran sulfate sodium (DSS)-mediated UC. Therefore, male BALB-c m...
Esraa G. El-Waseif, Manar A. Nader, Aamal G. El-Waseif et al.· European Journal of Pharmaco...· 0 citations
Prolonged or high dexamethasone (DEXA) exposure can promote steatohepatitis-like liver injury through insulin resistance, oxidative stress, inflammation, mitochondrial dysfunction, and fibrosis. Sacubitril/valsartan (Entresto) exhibits metabolic, anti-inflammatory, and antifibrotic properties that may protect again...
Mutni Kh. Alreshidi, Karim M. Saad, M. Zaghloul et al.· Frontiers in Pharmacology· 0 citations
PURPOSE
To investigate the antiseizure and neuroprotective effects of empagliflozin (EMPA), administered alone or in combination with levetiracetam (LEV), in pentylenetetrazole (PTZ)-induced epilepsy model in rats.
METHODS
A modified window-PTZ kindling model was used to investigate associated biochemical and molecul...
A. Madkour, Mahmoud Elshal, Rania R. Abdelaziz et al.· Neurotoxicology· 0 citations
Findings demonstrate associations between carvedilol treatment and multiple pathological processes during PTZ-induced kindling, but do not establish direct pathway-specific causality.
Ahmed H. Madkour, Rania R. Abdelaziz, Manar A. Nader et al.· Scientific Reports· 0 citations
Results indicate that mangiferin confers nephroprotection against TAC-induced renal injury that is highly associated with the modulation of oxidative stress, NLRP3 inflammasome, VEGF signaling, and PI3K/AKT/PTEN-mediated autophagy and apoptosis.
Naif S. Alharbi, Omnia Nour, M. Makled et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
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