Efficient Deduction of Encoded Local Response Within a Thermodynamically Perturbed Folded Protein
Externally imposed perturbations can subtly reshape protein structure and mechanics prior to the emergence of global unfolding signatures. Delineating locally sensitive zones, however, can pose immense challenges. Subjecting a small folded protein to isotropic pressure spanning 0.001 to 10 kbar, we develop a simplified...