Author

Manisha Nidhar

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Review Aug 2026

Purine-centred fused, conformationally constrained, and ring-expanded analogues in antitumor and antiviral drug discovery: A comprehensive review.

Purine-derived scaffolds remain important in anticancer and antiviral drug discovery because their electronic properties, hydrogen-bonding capacity, and conformational adaptability support interactions with kinases, polymerases, nucleotide-processing enzymes, and nucleic acids. This review critically examines three maj...

Manisha Nidhar, P. Alam, M. Alqarni et al. · European journal of medicina... · 0 citations

Open access Sep 2026

TPGS-stabilized pyrimethamine micelles promote ROS-associated apoptosis in MDA-MB-231 cells and suppress tumour progression in a murine lymphoma model

TPGS–pyrimethamine micelles enhance cellular uptake and are associated with increased ROS generation, apoptosis, and cell-cycle alterations in MDA-MB-231 cells, together with tumour suppression in a murine lymphoma model, which support further preclinical investigation of TPGS-based pyrimethamine micelles as a potentia...

Indrajeet Yadav, Manisha Nidhar, Pavan Goud et al. · DARU Journal of Pharmaceutic... · 0 citations

Jul 2026

Design, synthesis, in silico, in vitro and in vivo anticancer potential of sulphonamide- ethylamine-triazole-aryl in against triple negative breast cancer and Dalton lymphoma.

It is suggested that 4c exerts anticancer activity through ROS-mediated mitochondrial apoptosis and cell-cycle disruption, highlighting its promise as an oncotherapeutic candidate for TNBC and Dalton lymphoma.

Priyanka Sonker, Rupen Tamang, Priyanka Yadav et al. · Bioorganic chemistry (Print) · 1 citation