TPGS–pyrimethamine micelles enhance cellular uptake and are associated with increased ROS generation, apoptosis, and cell-cycle alterations in MDA-MB-231 cells, together with tumour suppression in a murine lymphoma model, which support further preclinical investigation of TPGS-based pyrimethamine micelles as a potential anticancer delivery strategy.
A poly(2-oxazoline) micelle (POx) platform co-encapsulating paclitaxel (PTX) and metronidazole benzoate (MB) to achieve concurrent delivery of anticancer and antibacterial agents is reported, highlighting the potential of POx micelles as a versatile platform for targeting both cancer cells and tumor-associated pathogen...
Alyssa Holden, Hallie Hutsell, L. Palchak et al.· Biomedical microdevices· 0 citations
Background: Ovarian cancer is frequently diagnosed at an advanced stage and remains one of the most lethal gynecologic malignancies. The development of multidrug resistance (MDR) during repeated chemotherapy is a major cause of treatment failure and is often associated with increased drug efflux mediated by transporter...
Myeong Kyun Yoo, Su Jeong Kang, Min Jeong Jo et al.· Pharmaceutics· 0 citations
The escalating global burden of multidrug-resistant (MDR) infections and cancer necessitates the development of sustainable and multifunctional therapeutic strategies. Green-synthesized zinc oxide nanoparticles (ZnONPs) have emerged as promising nanomaterials owing to their unique physicochemical properties, broad-spec...
Gamal M. El-Sherbiny, Dina M. Elkhashab, M. E. Shehata et al.· Scientific Reports· 1 citation
Overall, the cytotoxic effects of 7k on MV4-11 cells are attributed to the coordinated induction of ROS-mediated oxidative stress, G0/G1 cell cycle arrest, and caspase-dependent apoptosis, highlighting its promising antiproliferative potential.
A glutathione-responsive nanocarrier system based on poly(lactic-co-glycolic acid) (PLGA) was designed, which introduced disulphide bonds that are stable in extracellular environments but cleaved in a reductive intracellular environment enriched with glutathione, demonstrating promising therapeutic efficacy.
Abhay Dev Tripathi, S. Katiyar, Vivek K. Chaturvedi et al.· Journal of drug targeting (P...· 0 citations
This findings demonstrate that E-R@ISSL achieved coordinated DNA damage, ferroptosis, and ICD induction through its dual-targeted and sequentially activated co-delivery of ETP and LA, concurrently dismantling the GSH/GPX4 antioxidant defense and intensifying oxidative injury.
Yan Wang, Chao-Zheng Zhang, Chen Sun et al.· Theranostics· 0 citations
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