A Single-Administration AAV Gene Therapy Expressing an Affinity-Detuned Feline AIM (m-fAIM) for Chronic Kidney Disease in the Domestic Cat: A Theoretical Development Program
This work presents a theoretical development program for a single-administration adeno-associated virus (AAV) gene therapy designed to treat chronic kidney disease (CKD) in the domestic cat. The approach centers on the delivery of an affinity-detuned variant of feline Apoptosis Inhibitor of Macrophage (m-fAIM), enginee...