Author

Marcus D. Hartmann

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Open access Aug 2026

Cereblon on Steroids: Beyond the Canonical Ligand Space

Cereblon (CRBN) is widely used in targeted protein degradation, but its ligand space has remained dominated by a narrow set of cyclic imide chemotypes. Here, we show that the accessible CRBN ligand space extends substantially beyond this canonical space. A high-throughput screen of > 40,000 compounds, followed by ortho...

Alexander Herrmann, C. Heim, Samuel A. Maiwald et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Building coiled coils with polar cores

Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices. While these residues are predom...

Marcus D. Hartmann, B. H. Alvarez, Mikel Martinez-Goikoetxea et al. · Protein Science · 0 citations

Open access Aug 2026

Chaperone structure is not a sufficient determinant for the hierarchy of substrate secretion in bacterial type III secretion systems

It is shown that the gene linkage of SscB and SseF is critical for these proteins’ stability and SseF secretion and that chaperone structure is not a sufficient molecular determinant for the correct order of substrate secretion.

S. V. Pais, Pauline Fauser, Sarah Schroth et al. · bioRxiv · 0 citations