Author

Maxim Averbukh

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Open access Sep 2026

Evaluating pharmacological targeting of actin regulatory pathways during aging in C. elegans

Actin is a highly conserved cytoskeletal protein that regulates numerous cellular processes essential for tissue homeostasis and healthy aging. Although genetic studies have established important roles for actin and actin-binding proteins in longevity, pharmacological approaches offer complementary advantages for manip...

Tiffany Wang, Athena Alcala, Daniella Berdan et al. · Biogerontology (Dordrecht) · 0 citations

Open access Aug 2026

Form and function of actin impacts actin health and aging

How genetic and pharmacologic perturbations of actin structure and function influence lifespan and various hallmarks of aging in Caenorhabditis elegans is interrogated, providing a comprehensive and publicly accessible resource that maps, for the first time, how changes in actin integrity correlate with diverse aging p...

Maxim Averbukh, Hunter T. Nelson, Tiffany Wang et al. · iScience · 2 citations

Open access Aug 2026

Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity

It is shown that the neuronal expression of the chromatin reader BET-1 promotes longevity and resilience in C. elegans through signaling mechanisms involving master transcription factors HSF-1 and DAF-16 and neurotransmitter UNC-13.

Naibedya Dutta, Daniel Hicks, Edgar Esparza et al. · Genes & Development · 0 citations