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Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity

Naibedya Dutta Daniel Hicks Edgar Esparza Anna Entin Priyadharshini Vijayakumar Caitlin M. Lange Tripti Nair Elijah A. Roditi Athena Alcala Maxim Averbukh Matthew Vega Rebecca Aviles Barahona Caitlin McTygue Veronica Kuo Juri Kim Herbert Anson A. Coakley George Wang Steven E. Pilley Max A. Thorwald Whitaker Cohn Sean P. Curran N. Brouilly Caroline Kumsta Rachel N. Arey Peter J. Mullen Gilberto Garcia Ryo Higuchi-Sanabria
Aug 2026 · Genes & Development · Vol 40, pp. 1523 - 1552 · 0 citations · 141 references
Medicine

TL;DR

It is shown that the neuronal expression of the chromatin reader BET-1 promotes longevity and resilience in C. elegans through signaling mechanisms involving master transcription factors HSF-1 and DAF-16 and neurotransmitter UNC-13.

Abstract

In this study, Dutta et al. show that the neuronal expression of the chromatin reader BET-1 promotes longevity and resilience in C. elegans. Neuronal BET-1 activates various prolongevity transcriptional programs—including proteostasis, immune response to pathogens, and metabolism—through signaling mechanisms involving master transcription factors HSF-1 and DAF-16 and neurotransmitter UNC-13.

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