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A computer simulation of a simple exclusion model faithfully recapitulated wildtype and mutant spindle position phenotypes support a volume exclusion model for positioning acentriolar meiotic spindles.
Proteomics is a powerful tool for profiling the protein landscape underlying cellular and physiological processes. Advances in mass spectrometry-based methods, such as tandem-mass-tags (TMT) isobaric labeling-based proteomics at both MS2 and MS3, label-free quantification (LFQ) with data-dependent-acquisition (DDA) or...
How genetic and pharmacologic perturbations of actin structure and function influence lifespan and various hallmarks of aging in Caenorhabditis elegans is interrogated, providing a comprehensive and publicly accessible resource that maps, for the first time, how changes in actin integrity correlate with diverse aging p...
It is demonstrated that TEMI overcomes the long-standing spatial limitations of MSI without requiring hardware modifications, ensuring compatibility with existing MSI instruments and promoting broad accessibility and adoption within the research community.
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