Probing the native state of a two-state folding protein by high pressure NMR spectroscopy.
Intramolecular distances existing between the sheets that define the β-barrel fold of BsCspB have been shown to respond nonuniformly to increasing hydrostatic pressure, suggesting that the three-dimensional structure of native BsCspB is modified such that β-strands depart from each other.
Frédéric Berner, Michael Kovermann
· Biophysical Journal · 0 citations