Evolution of the SARS-CoV-2 Main Protease Under Fitness Constraints Imposed by Folding Stability and Activity.
Overall, SARS-CoV-2 Mpro evolution is strongly constrained by structural and functional requirements, supporting the suitability of this protein as an effective antiviral target and suggesting that incorporating viral evolutionary dynamics may help inform the design of therapeutic strategies with improved long-term rob...
David Ferreiro, Miguel Arenas
· Proteins: Structure, Functio... · 0 citations