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Author

Ming Chen

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Jul 2026

Mechanism of TRIM32 regulation of synaptic protein expression in the development of epilepsy in a rat model.

It is suggested that TRIM32 regulates synaptic protein expression in epilepsy and that its deficiency worsens anxiety-like behavior, cognitive impairment, and synaptic loss by perturbing BDNF/TrkB/CREB signaling, thereby providing insights that may inform future therapeutic strategies targeting this signaling pathway.

Ming Chen, Jingrong Pei · 0 citations
Open access Jul 2026

Explainable XGBoost model and nomogram for risk factor identification and risk prediction in cerebral small vessel disease: a machine learning-based retrospective cohort study

An interpretable XGBoost-based ML model that facilitates early risk stratification and targeted interventions for CSVD is validated, readily transferable to resource-limited settings and on embedding the nomogram into electronic-health-record decision support.

Xi Zhu, Xu-Hui Liu, Xujie Wang et al. · 0 citations

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