Modulation of Nrf2/TNF-α and TLR4/TGF-β1 Signaling Pathways by Nigella Sativa Oil and Echinacea Purpurea Extract Attenuates Cyclosporine A-Induced Nephrotoxicity and Immunotoxicity.
The combination therapy most effectively normalized oxidative balance, suppressed TNF-α, enhanced Nrf2, mitigated the expression of renal injury genes, and significantly restored the expression of key bone marrow cytokines towards control levels, concurrently improving serum creatinine, urea, and hematological profiles...