Modulation of Nrf2/TNF-α and TLR4/TGF-β1 Signaling Pathways by Nigella Sativa Oil and Echinacea Purpurea Extract Attenuates Cyclosporine A-Induced Nephrotoxicity and Immunotoxicity.

Targeting TRAF6/MYD88/TLR4, Nrf2, and VEGF signaling pathways by Tranexamic acid as a Novel Therapeutic Approach Protects Against Isotretinoin-Induced Liver Toxicity in Rats.

TXA effectively protects against isotretinoin-induced hepatotoxicity, primarily through antioxidant and anti-inflammatory mechanisms, primarily through antioxidant and anti-inflammatory mechanisms.

Involvement of NOD1/NF-κB/MAPK pathway in the protective effect of procyanidin B2 against methotrexate-induced nephrotoxicity

Objective Methotrexate (MTX) is a very effective agent used to treat rheumatoid arthritis and malignant diseases. Despite its usefulness, the long-term use of MTX is associated with multiorgan toxicities, including kidney injury. Thus, there is a necessity to explore a renoprotective agent with low side effects. Procya...

Epigallocatechin-3-gallate as a hepatoprotective agent against ochratoxin a: modulating ER stress and NF-κB/TNF-α/IL-6 responses

It is demonstrated that OTA-induced hepatotoxicity may be mediated, at least in part, through modulation of ER stress and NF-κB-driven inflammatory cascades, and that EGCG demonstrated dose-dependent protection by attenuating these responses.

Obeticholic Acid and Edaravone Protect Against Cisplatin‐Induced Hepatotoxicity Through Modulation of Keap1/Nrf2/ARE, TNF‐α/NF‐κB, and AKT/GSK‐3β Pathways

It is suggested that OCA and EDA, particularly in combination, attenuate CP‐induced hepatotoxicity and are associated with coordinated modulation of oxidative stress, inflammatory signaling, and AKT/GSK‐3β‐associated pro‐survival/pro‐death pathways.

Nrf2/BAX/Bcl2 Signaling Crosstalk and Histopathological Correlates of Renoprotection by Black Soldier Fly Larval Oil Against Aflatoxin B1-Induced Oxidative and Inflammatory Kidney Injury in Rats

Background Aflatoxin B1 (AFB1) is a highly hazardous mycotoxin commonly detected in contaminated food supplies and poses serious health risks to both humans and animals. Although its hepatotoxic effects are well established, the kidney, a principal organ for toxin elimination, remains highly susceptible to AFB1-induced...

18β-glycyrrhetinic acid ameliorates ifosfamide-induced nephrotoxicity by suppressing Wnt3a/IL-17A-driven inflammatory signaling, ER stress, and apoptosis while preserving ZO-1 integrity.