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Author

Mohamed R. Elnagar

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Open access Sep 2026

Discovery of tricyclic benzo[4,5]imidazo[2,1-b]thiazole-3-hydroxyindolin-2-one hybrids as selective MAO-B and cholinesterase inhibitors

A series of 13 novel 3-hydroxyindolin-2-one-benzo[4,5]imidazo[2,1-b]thiazole hybrids was designed, synthesized, and evaluated as potential anti-Alzheimer agents targeting monoamine oxidase B (MAO-B) and cholinesterases. The target compounds were obtained by condensing a benzo[4,5]imidazo[2,1-b]thiazole-based ketone wit...

Wagdy M. Eldehna, Ashraf K. El-Damasy, Jaeyeop Lim et al. · 0 citations
Open access Aug 2026

Quinazolinone–triazole hybrids as multi-target-directed ligands for Alzheimer's disease: discovery of potent and selective MAO-B inhibitors with cholinesterase modulating activity

A new series of quinazolinone–triazole hybrids (QTHs, 5a–n) was designed, synthesized, and evaluated as potential multi-target-directed ligands for Alzheimer's disease. All synthesized compounds were screened against human monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). The obtained results revealed pronou...

Wagdy M. Eldehna, Ashraf K El-Damasy, Jaeyeop Lim et al. · 1 citation
Open access Sep 2026

Design, synthesis, and molecular modeling of quinoline-linked diphenylpyrazoles as multitarget EGFR, VEGFR-2, and COX-2 inhibitors with anticancer, anti-inflammatory and apoptosis-inducing properties.

A new series of quinoline-diphenylpyrazole hybrids were rationally designed, synthesized, and biologically evaluated as potential EGFR/VEGFR-2/COX-2 inhibitors, supporting the proposed hybrid design strategy.

Abdelrahman Hamdi, Mohamed R. Elnagar, M. Hussein et al. · 0 citations
Open access Jul 2026

Design, synthesis, molecular docking and molecular dynamics simulations of pyrazolo[3,4-d]pyrimidine scaffolds as selective COX-2 and CDK2 kinase inhibitors with dual anti-inflammatory and anti-proliferative activities

A new series of pyrazolo[3,4-d-d]pyrimidine scaffolds, namely, 4a–l, were designed, synthesized, and tested for anti-inflammatory and anti-proliferative activities and represent promising starting candidates for the development of future CDK2 kinase and COX-2 inhibitors.

Sara Y. Ewieda, Laila Ziko, Ahmed Elshewy et al. · 1 citation
Open access Aug 2026

Targeting CDK‐2 With Novel Indole‐Pyrazole Hybrids: Discovery of Potent Anticancer Agents Supported by Mechanistic and In Silico Studies

The consistent binding of compound 5 d within the ATP‐binding pocket of CDK‐2 was confirmed by molecular docking and molecular dynamics simulations, and attractive drug‐like and pharmacokinetic features, similar to those of Roscovitine, were demonstrated by in silico ADMET predictions.

Wagdy M. Eldehna, Zainab M. Elsayed, Mohamed R. Elnagar et al. · 0 citations
Open access Aug 2026

Novel benzofuran-1,3,4-thiadiazole aryl urea hybrids as dual VEGFR-2/BRAF inhibitors: anticancer activity, apoptosis induction, and molecular modeling studies.

A novel series of benzofuran-based aryl urea derivatives incorporating a 1,3,4-thiadiazole linker were designed as dual VEGFR-2/BRAFWT inhibitors using sorafenib as a pharmacophoric template, with compound 7j emerging as the most active analogue.

Marwa I. Serag, Mohamed R. Elnagar, Wafaa A. Ewes et al. · 1 citation

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