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Muhammad Saad Ul Hassan

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#protein folding Open access Oct 2026

Downstream mRNA Secondary Structure, Not Codon Elongation Supply, Coordinates Co-Translational Protein Folding Across the Human Ribosomal Exit Tunnel

While the overall effect size is modest, accounting for approximately 0.49% of local packing variance; its spatial specificity and consistency across independent structural metrics suggest that downstream mRNA stability acts as a localized mechanical brake during early chain compaction.

Muhammad Saad Ul Hassan, Ishrat Jabeen, Yusra Sajid Kiani · 0 citations
#protein folding Dataset Open access Sep 2026

Harmonized Residue-Level Dataset of Human Co-Translational Protein Folding Kinetics and Downstream mRNA Secondary Structure (1,270 Non-Redundant Proteins)

Overview This dataset contains residue-level biophysical measurements, translational kinetics profiles, and downstream mRNA thermodynamic stability metrics across 1,270 non-redundant human proteins (410,151 total residue observations). The dataset is designed to benchmark whether co-translational protein folding is pac...

Muhammad Saad Ul Hassan · 0 citations
#protein folding Dataset Open access Sep 2026

Harmonized Residue-Level Dataset of Human Co-Translational Protein Folding Kinetics and Downstream mRNA Secondary Structure (1,270 Non-Redundant Proteins)

Overview This dataset contains residue-level biophysical measurements, translational kinetics profiles, and downstream mRNA thermodynamic stability metrics across 1,270 non-redundant human proteins (410,151 total residue observations). The dataset is designed to benchmark whether co-translational protein folding is pac...

Muhammad Saad Ul Hassan · 0 citations

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