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Murilo N. Sanches

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#protein folding Dataset Open access Sep 2026

Local Frustration Modulates the Folding Dynamics of a Repeat Protein

Repeat proteins fold through pathways that are strongly shaped by local energetics, making them highly sensitive to mutations. The ankyrin repeat (AR) domain of IκBα is a cooperative folding unit in which the first four repeats (AR1–AR4) are stable, while the last two are destabilized. Despite this simple modular archi...

Murilo N. Sanches, María Inés Freiberger, Peter G. Wolynes et al. · 0 citations
#protein folding Dataset Open access Sep 2026

Local Frustration Modulates the Folding Dynamics of a Repeat Protein

Repeat proteins fold through pathways that are strongly shaped by local energetics, making them highly sensitive to mutations. The ankyrin repeat (AR) domain of IκBα is a cooperative folding unit in which the first four repeats (AR1–AR4) are stable, while the last two are destabilized. Despite this simple modular archi...

Murilo N. Sanches, María Inés Freiberger, Peter G. Wolynes et al. · 0 citations

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