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Author

Mustafa Nazıroğlu

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Open access Sep 2026

Resveratrol mitigates hypoxia-induced mitochondrial oxidative damage and apoptosis via inhibition of TRPA1 channel in retinal pigment epithelial cells.

HBO exposure through TRPA1-mediated Ca2+ signaling, induces mitochondrial oxidative cell cytotoxicity and death, which may offer a treatment option for HPO-induced retinal disorders linked to increased OFR and Ca2+ influx.

M. Argun, Mustafa Nazıroğlu · 0 citations
Aug 2026

Psalmotoxin-1, a novel TRPM2 channel antagonist, reduces age-related macular degeneration-caused mitochondrial oxidative damage and apoptosis in human retinal pigment epithelial (ARPE-19) cells.

PSTX incubation blocked TRPM2-mediated Ca2+ signaling, reducing AMD-induced mitochondrial oxidant injury and cell death and PSTX, a new TRPM2 antagonist, may be utilized to treat oxidative stress and aberrant Ca2+ influx induced by AMD.

Dilek Özkaya, Mustafa Nazıroğlu · 0 citations

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